In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur.
Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:. For safe and effective use of this medicine, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor.
Taking too much of this medicine may increase the chance of unwanted effects. Do not change the dose or stop using this medicine without checking first with your doctor. This medicine should come with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions. Misoprostol is best taken with or after meals and at bedtime, unless otherwise directed by your doctor.
To help prevent loose stools, diarrhea, and abdominal cramping, always take this medicine with food or milk. No clinically significant adverse, hematological or biochemical effects have been reported.
Two studies suggested that misoprostol reduced the adverse effect of smoking on the healing of duodenal ulcer. Misoprostol is similar to naturally made protective substances in your body, called prostaglandins. Prostaglandins help to protect the lining of your stomach and intestines. Taking misoprostol will help prevent you from getting ulcers in your stomach and the part of your intestines next to your stomach, which is called the duodenum. Ulcers in these areas are often caused by taking painkillers known as non-steroidal anti-inflammatory drugs or NSAIDs for short.
Two common examples of these medicines are diclofenac and naproxen - medicines often taken by people with arthritis. NSAIDs can reduce the natural amount of prostaglandins in your stomach and intestines, which causes indigestion and can lead to ulcers forming. Misoprostol tablets will replace your natural prostaglandins so that you can continue getting benefit from your NSAID painkiller.
If you already have an ulcer, misoprostol will help it to heal. Combination brands of tablet are sometimes prescribed for people with arthritis. Taking a combination tablet can help to reduce the total number of tablets that you need to take each day. Occasionally, misoprostol may be prescribed for a use which is not covered by this leaflet. If you have been prescribed misoprostol for a reason other than those listed above, you should ask your doctor if you have any questions about your treatment.
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking misoprostol it is important that your doctor knows:.
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. Similarly, while in volunteers pretreatment with misoprostol is able to protect the gastric mucosa from alcohol damage, there is little clinical evidence to support improved ulcer healing in the patient who abuses alcohol. Further studies in these areas should be conducted. Misoprostol could well have an important role to play in the protection of the gastroduodenal mucosa from damage produced by non-steroidal anti-inflammatory drugs NSAIDs in arthritic patients compelled to take these drugs for long periods.
A series of double-blind placebo-controlled trials in healthy volunteers have shown that pretreatment with, or simultaneous administration of, micrograms daily of misoprostol, reduces significantly mucosal damage produced by aspirin, tolmetin and naproxen.
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